30^th World Congress on Vaccines and Immunization October 22-23, 2018 Osaka, Japan

CHEN Wei has his expertise in vaccination management and information work, and extensive experience in vaccination technology, cold chain equipment monitoring, media broadcasting and communication. He conducted the construction of the Tianjin vaccination information system, greatly improved the efficiency and security of work. He was responsible for the monitoring and treatment of infectious diseases, such as Epidemic cerebrospinal meningitis, Japanese encephalitis, Pertussis and neonatal tetanus, so good at the outbreak analysis and disposal

Statement of the Problem: The success of children vaccination is related to the knowledge and trust of their parents. The illegal vaccine sales in Shandong province event undermine the public confidence to vaccination. In order to further strengthen vaccine management and rebuild public confidence, the State Council has made major changes to the management regulations of Category II vaccines in China. The main objective of this study was to learn the awareness and attitude of parents for vaccination and the implementing updated regulations for Category II vaccines and insight into the needs of the public and broadcasting effects. Method: Sampling respectively two immunization clinics every district from 16 districts in Tianjin, 25 parents of children under three years old were selected by convenience sampling in each clinic on May-April 2017, investigated the general situation of subjects, the attitude to vaccination, the awareness to updated regulations for Category II vaccines, the channel to acquire knowledge and demand. Findings: 900 children’s parents were investigated, 99.11% trusted vaccination, most parents could recognize wrong acknowledge. Only 38.44% of parents knew the updated regulations for Category II vaccines. The main information that parents wanted to receive were vaccine safety and effectiveness, respectively were 68.33%, 55.67%. The key channel to acquire immunization knowledge was from immunization doctor, which occupied 69.89% and then were manual book and mobile APP which, respectively were 64.00% and 31.33%. Conclusion: We need to strengthen the immunization education for children’s parents in Tianjin, increase children parents understanding of updated regulations, and specially adjust the content and way of health education.

Israel Solano is a grad student at the National Institute of Public Health in Mexico. He has professional studies in genetics and molecular biology and his research interest are focused on evolutionary process. Now he is using the tools and methods of population biology and mathematics to infectious diseases to find novel ways to predict outbreaks, their outcome and simulate the impact of control strategies. He is a passionate, responsible adaptable and creative researcher that is always eager to find and apply innovative approaches to long withstanding problems. Email: Israel.

DENV causes a major viral infection reported widely in tropical regions around the world. To date, the mechanism of viral replacement and persistence is unknown. In endemic regions where the four serotypes cocirculate, the re-emergence of genetic variants that have circulated in the past has been reported. This phenomenon may have different causes such as vector density, silent transmission between asymptomatic hosts or reintroduction from nearby regions. Furthermore, evidence of positive selection and clade fixation has been shown for this disease. Seeing that most of these events occur in the background and surveillance systems may not notice them promptly, epidemiological and ecological factors that favor the emergence of better-adapted lineages are unknown. Furthermore, we do not know the effect of an intervention, such as vaccination, on the emergence of this strains. Dengue vaccines, licensed and in development, are regarded as imperfect because they do not confer complete protection against the four serotypes. Therefore, identification and parametrization of the viral escape efficiency in response to a vaccine is an undeveloped area for dengue research. Mathematical modeling is a valuable tool that will allow us to take on this task as it is an efficient way to synthesize epidemiological and evolutive knowledge of diseases. Herein, we model the dynamics of the four dengue serotypes following the introduction of either one or two vaccines in an endemic population in Mexico to assess its effects over the viral populations. We propose that if immunity exerted by the vaccine reaches a threshold then the velocity at which variants emerge will slow down and the vaccine will have a longstanding effect. On the contrary, if this threshold is not reached dengue cases could return to its previous state and a previously unfavored serotype could make its way into hosts populations.